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KMID : 1094020070240030400
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Journal of Veterinary Clinics
2007 Volume.24 No. 3 p.400 ~ p.405
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The Therapeutic Effect of Hovenia dulcis Thunberg Extracts and 6 Types of Herbal Extracts on CCl₄- induced Acute Liver and Kidney Damages in Rats
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Lim Mee-Kyung
Kim Ju-Wan
Kim Ji-Eun
Kim Hong-Tae
Jung Sang-Ju
Kang Mi-Young
Lee Keun-Woo
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Abstract
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This study was performed to investigate the therapeutic effects of Hovenia dulcis Thunberg (HDT) and HDTmix extracts on the biochemical analysis, histopathology and histomorphometry of liver and kidney in carbon tetrachloride administrated rats. Extract was prepared by autoclave (, 15 psi, 3 hours) and filtered with nylon cloth and filter paper then freezing dried. In blood chemistry analysis, HDTmix group, aspartate aminotransferase and alanine aminotransferase were significantly (p<0.01) decreased compared to the group, on 3rd day, respectively. In histologic and histomorphometry analysis, the hepatopathies and nephropathies were dramatically decreased (3rd, 5th day), and well corresponded to the histopathological changes significantly (p<0.01) decreases of degenerative regions, degenerative cells and glomeruli were detected in liver and kidney with significantly decreases of group. HDTmix group, quite similar effects on the liver and kidney were observed compared to that of HDT extracts group but more favorable efficacies were detected especially HDTmix also inhibit the hepatopathies (1 day), in which HDT extract does not showed any inhibit effects.
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KEYWORD
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Hovenia dulcis Thunberg, carbon tetrachloride, hepatotoxicity
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